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A new study links the abuse of anabolic steroids like testosterone to metabolic disease through insulin resistance. The study, published in the Journal of Nutrition, found that the abuse of anabolic steroids caused insulin resistance, which in turn increased a metabolic risk factor in mice. The study is the first to find an association between the abuse of anabolic steroids and metabolic disease in mouse models. "Tests done on humans indicate an elevated risk for diabetes and cardiovascular disease," lead author Aimee K. Lee of the Institute for Research on Human Nutrition at The Catholic University of America in Washington, D.C., and lead author of the study, "Insulin resistance and metabolic risks associated with abuse of anabolic steroids in male mice," says the study. Insulin resistance is a common condition in which the pancreas, normally involved in delivering glucose when needed, has become unable to do so. Studies have shown that insulin secretion in the blood has a direct link to insulin resistance. Diabetes is a disease in which blood sugar levels stay too low, leading to a buildup of fat in the body. The researchers tested mice on anabolic steroids and measured the mice's metabolic effects — including insulin resistance — before and after they began using the steroid. Koenig says that this is one of the more rigorous studies that could be conducted. "This is not a very rigorous study, but the way it got done required a lot of experimentation. Other studies have also demonstrated this. It is the first to show it directly in a mouse model," he says. The researchers say that using anabolic steroids may encourage fat accumulation. The study found that once the mice were placed on anabolic steroids, their fat mass increased substantially. This was a very surprising finding, the researchers say, "given the known effect of steroids on metabolism, which is to reduce fat mass." "Our study suggests that this is an important factor in the onset of metabolic disease in these mice, not only in humans but also in mice," Lee says. She says some may argue that these mice are inbred, meaning they may be more susceptible to drug abuse because they are bred for increased endurance. But, she says, that also increases risk of metabolic disease. "One could argue that the more extreme anabolic steroids used, the more likely they are to be abused," Lee says. "But this study suggests that this is not the case among this animal model." She stresses that other studies have found similar results in mice. "This study was designed to mimic the effects that an Similar articles: